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課程名稱 |
高等有機化學一
ADVANCED ORGANIC CHEMISTRY (I) |
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開課學期 |
96-2 |
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授課對象 |
理學院 化學所化學組 |
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授課教師 |
蔡蘊明 |
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課號 |
Chem7027 |
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課程識別碼 |
223 M1230 |
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班次 |
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學分 |
4 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期一3,4(10:20~12:10)星期五3,4(10:20~12:10) |
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上課地點 |
新503新503 |
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備註 |
僅限有機組學生修習此課程。本課程中文授課,使用英文教科書。本課程?
限碩士班以上 且 限本系所學生(含輔系、雙修生)
總人數上限：50人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/962ymt |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
本課程以化學所有機組碩士班與博士班學生為授課對象，為有機組之必修課程。學程半年，為4學分課程。非有機組以及藥學系的學生應去修羅禮強教授開給化學生物組的高等化學生物學，其實質內容亦為有機合成。 |
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課程目標 |
本課程使用之教材並非最新的版本，實際上已經有第五版，內容因為我未曾看過所以不知道更新的狀況如何，但是本課程乃以第四版為基準定出教學大綱，又因該書內容極多，不可能所有內容一一含蓋，僅挑選其中最常用及重要的一些合成試劑及反應來討論，並加入一些我認為需要的內容。希望在本部份結束時，學生能對重要的官能基轉換及建立碳-碳鍵的方法有好的掌握。我會將課程講義事前放上Ceiba，上課以板書方式，但是我寫黑板的速度很快，抄我的板書會漏聽我口頭的說明。 |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
每週三 17:30~18:30 |
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指定閱讀 |
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參考書目 |
教課書：
F.A. Carey and R.A. Sundberg "Advanced Organic Chemistry,
Part B: Reactions and Synthesis (4th Edition)." Plenum
Press。
其它參考書目(已列入圖書館之課程參考書)：
題名/編著者/索書號
1 Advanced asymmetric synthesis / edited by G. R. Stephenson/QD262 A38z
1996
2 Asymmetric synthesis / edited by James D. Morrison/QD481 As99 v.2
3 Asymmetric synthesis / edited by James D. Morrison/QD481 As99 v.3
4 Basic organic stereochemistry / Ernest L. Eliel, Samuel H. Wilen,
Michael P. Doyle/QD481 E515 2001
5 Catalytic asymmetric synthesis / edited by Iwao Ojima/QD262 C357 2000
6 Classics in total synthesis II : more targets, strategies, methods /
K.C. Nicolaou and S.A. Snyder ; with a foreword by E.J. Corey/QD262 N52z 2003
7 Classics in total synthesis : targets, strategies, methods / K.C.
Nicolaou and E.J. Sorensen/QD262 N52 1996
8 Free radicals in organic chemistry / Jacques Fossey, Daniel Lefort,
Janine Sorba ; foreword by Alwyn Davies, Guy Ourisson ; translated by John
Lomas/QD471 F71513 1995
9 The logic of chemical synthesis / E.J. Corey and Xue-Min Cheng/QD262
C577z 1989
10 Main group metals in organic synthesis / edited by Hisahi Yamamoto
and Koichiro Oshima/QD411.7.S94 M33z 2004 v.1
11 Main group metals in organic synthesis / edited by Hisahi Yamamoto
and Koichiro Oshima/QD411.7.S94 M33z 2004 v.2
12 March's advanced organic chemistry : reactions, mechanisms, and
structure /QD251.2 M37 2001
13 Metal carbenes in organic synthesis / Florencio Zaragoza Dörwald
/QD305.H7 D67 1999
14 Modern organocopper chemistry / edited by Norbert Krause
/QD412.C9 M64 2002
15 Modern oxidation methods / edited by Jan-Erling Bäckvall/
QD281.O9 M6z 2004
16 Organic syntheses based on name reactions / A. Hassner and C. Stumer
/QD262 H324 2002
17 Organic synthesis : concepts and methods / Jürgen-Hinrich Fuhrhop,
Guangtao Li/QD262 F78z 2003
18 Organotin chemistry / Alwyn G. Davies/QD412.S7 D38 2004
19 Oxidations in organic chemistry / Miloš Hudlický/QD281.O9 H83 1990
20 Reductions by the alumino- and borohydrides in organic synthesis /
Jacqueline Seyden-Penne/QD63.R4 S4913 1997
21 Silicon in organic synthesis / Ernest W. Colvin/QD 412 S6 C726
22 Synthetic organic photochemistry / edited by Axel G. Griesbeck and
Jochen Mattay/QD275 S95 2005
23 Transition metals for organic synthesis : building blocks and fine
chemicals / edited by M. Beller and C. Bolm/QD262 T73z 2004 v.1
24 Transition metals for organic synthesis : building blocks and fine
chemicals / edited by M. Beller and C. Bolm/QD262 T73z 2004 v.2
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
期中考 |
50% |
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2. |
期末考 |
50% |
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3. |
隨堂測驗 |
0% |
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4. |
作業 |
0% |
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5. |
報告 |
0% |
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週次 |
日期 |
單元主題 |
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第1週 |
2/18,2/22 |
Chapter 1 Alkylation of nucleophilic carbon intermediates - enolates |
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第2週 |
2/25,2/29 |
Chapter 1 Alkylation of nucleophilic carbon intermediates - enolates
Chapter 2 Reactions of carbon nucleophiles with carbonyl groups |
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第3週 |
3/03,3/07 |
Chapter 2 Reactions of carbon nucleophiles |
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第4週 |
3/10,3/14 |
Chapter 2 Reactions of carbon nucleophilesChapter 3 Functional group interconversion by nucleophilic substitution
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第5週 |
3/17,3/21 |
Chapter 4 Electrophilic additions to C-C multiple bonds: S, Se and B
Chapter 5 Reduction |
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第6週 |
3/24,3/28 |
Chapter 5 Reduction
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第7週 |
3/31 |
Chapter 6 Cycloadditions and rearrangements |
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第8週 |
4/07,4/11 |
Chapter 6 Cycloadditions and rearrangements |
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第9週 |
4/14,4/18 |
Chapter 6 Cycloadditions and rearrangements |
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第10週 |
4/21,4/25 |
4/21 Midterm exam.
Chapter 6 Cycloadditions and rearrangements |
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第11週 |
4/28,5/02 |
Chapter 6 Cycloadditions and rearrangements |
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第12週 |
5/05,5/09 |
Chapter 7 Organometallic compounds of the group I, II, III metals
Chapter 8 Organometallics involving transition metals |
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第13週 |
5/12,5/16 |
Chapter 8 Organometallics involving transition metals
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第14週 |
5/19,5/23 |
Chapter 9 Compounds of B, Si and Sn in organic synthesis
Chapter 10 Reactions involving carbocations , carbenes and radicals |
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第15週 |
5/26,5/30 |
Chapter 10 Reactions involving carbocations , carbenes and radicals |
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第16週 |
6/02,6/06 |
Chapter 10 Reactions involving carbocations , carbenes and radicals
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Chapter 12 Oxidations |
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第17週 |
6/09,6/13 |
Chapter 12 Oxidations
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Final Chapter Some classics of natural product synthesis |
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